Keep an eye on Closely (one)pentobarbital will decrease the level or outcome of fentanyl transmucosal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to your lessen in fentanyl plasma concentrations, not enough efficacy or, quite possibly, progre